TAKAOMI C. SAIDO: search on Z-Library

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1

Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in

Chiasseu, Marius, Fesharaki-Zadeh, Arman, Saito, Takashi, Saido, Takaomi C., Strittmatter, Stephen M.

Journal:

Neurobiology of Disease

Year:

2020

File:

PDF, 7.82 MB

2020

2

Transient Brain Ischaemia Provokes Ca2+, PIP2 and Calpain Responses Prior to Delayed Neuronal Death in Monkeys

Tetsumori Yamashima, Takaomi C. Saido, Masatoshi Takita, Atsuo Miyazawa, Jun Yamano, Atsuo Miyakawa, Hisashi Nishijyo, Junkoh Yamashita, Seiichi Kawashima, Taketoshi Ono, Tohru Yoshioka

Journal:

European Journal of Neuroscience

Year:

1996

Language:

english

File:

PDF, 10.01 MB

english, 1996

3

Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

Szaruga, Maria, Munteanu, Bogdan, Lismont, Sam, Veugelen, Sarah, Horré, Katrien, Mercken, Marc, Saido, Takaomi C., Ryan, Natalie S., De Vos, Tatjana, Savvides, Savvas N., Gallardo, Rodrigo, Schymkowit

Journal:

Year:

2017

Language:

english

File:

PDF, 5.42 MB

english, 2017

4

Gene therapy in Alzheimer’s disease – potential for disease modification

Per Nilsson, Nobuhisa Iwata, Shin-ichi Muramatsu, Lars O. Tjernberg, Bengt Winblad, Takaomi C. Saido

Journal:

Journal of Cellular and Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

5

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

Purro, Silvia A., Farrow, Mark A., Linehan, Jacqueline, Nazari, Tamsin, Thomas, David X., Chen, Zhicheng, Mengel, David, Saito, Takashi, Saido, Takaomi, Rudge, Peter, Brandner, Sebastian, Walsh, Domin

Journal:

Year:

2018

Language:

english

File:

PDF, 4.56 MB

english, 2018

6

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC

Shigeo Ohno, Yoshiko Akita, Akiko Hata, Shin-Ichi Osada, Kyoko Kubo, Yasuhiko Konno, Kazunori Akimoto, Keiko Mizuno, Takaomi Saido, Toshio Kuroki, Koichi Suzuki

Journal:

Advances in Enzyme Regulation

Year:

1991

Language:

english

File:

PDF, 1.00 MB

english, 1991

7

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

Shirotani, Keiro, Hori, Yuma, Yoshizaki, Ryohei, Higuchi, Eri, Colonna, Marco, Saito, Takashi, Hashimoto, Shoko, Saito, Takashi, Saido, Takaomi C., Iwata, Nobuhisa

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.49 MB

english, 2019

8

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Rice, Heather C., Marcassa, Gabriele, Chrysidou, Iordana, Horré, Katrien, Young-Pearse, Tracy L., Müller, Ulrike C., Saito, Takashi, Saido, Takaomi C., Vassar, Robert, de Wit, Joris, De Strooper, Bart

Journal:

Molecular Neurodegeneration

Year:

2020

Language:

english

File:

PDF, 2.38 MB

english, 2020

9

10.1038/77399

Iwata, Nobuhisa, Tsubuki, Satoshi, Hama, Emi, Takaki, Yoshie, Shirotani, Keiro, Saido, Takaomi C.

Journal:

Nature Medicine

Year:

2000

Language:

english

File:

PDF, 300 KB

english, 2000

10

CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease

Yun-Sik Choi, Boyoung Lee, Hee-Yeon Cho, Iza B. Reyes, Xin-An Pu, Takaomi C. Saido, Kari R. Hoyt, Karl Obrietan

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 5.51 MB

english, 2009

11

Age-Related Amyloid β Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid β Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss

Ayano Takeuchi, Michael C. Irizarry, Karen Duff, Takaomi C. Saido, Karen Hsiao Ashe, Masato Hasegawa, David M.A. Mann, Bradley T. Hyman, Takeshi Iwatsubo

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 917 KB

english, 2000

12

P1-234 Contribution of calpains and caspases to Abeta-induced neuritic and synaptic pathologies in Alzheimer's disease patients and amyloid precursor protein transgenic mice

Makoto Higuchi, Jiro Takano, Nobuhisa Iwata, Misaki Sekiguchi, Takaomi C. Saido

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 168 KB

english, 2004

13

Evidence for the involvement of calpain in cataractogenesis in Shumiya cataract rat (SCR)

Mitsushi Inomata, Kohji Nomura, Makoto Takehana, Takaomi C Saido, Seiichi Kawashima, Seigo Shumiya

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

1997

Language:

english

File:

PDF, 711 KB

english, 1997

14

O2-04-06: New lessons form the APP/PS1 transgenic mouse model with neuron loss: Metal biology, axonal degeneration and intraneuronal N-modified Aβ aggregation

Thomas A. Bayer, Oliver Wirths, Stephanie Schäfer, Henning Breyhan, Martina Muckenthaler, André Delacourte, Rakez Kayed, Takaomi Saido, Gerd Multhaup, Joachim Weis

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 68 KB

english, 2006

15

New Mouse Model of Alzheimer’s

Nilsson, Per, Saito, Takashi, Saido, Takaomi C

Journal:

ACS Chemical Neuroscience

Year:

2014

Language:

english

File:

PDF, 3.17 MB

english, 2014

16

APP mouse models for Alzheimer's disease preclinical studies

Sasaguri, Hiroki, Nilsson, Per, Hashimoto, Shoko, Nagata, Kenichi, Saito, Takashi, De Strooper, Bart, Hardy, John, Vassar, Robert, Winblad, Bengt, Saido, Takaomi C

Journal:

The EMBO Journal

Year:

2017

Language:

english

File:

PDF, 903 KB

english, 2017

17

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology

Nagata, Kenichi, Takahashi, Mika, Matsuba, Yukio, Okuyama-Uchimura, Fumi, Sato, Kaori, Hashimoto, Shoko, Saito, Takashi, Saido, Takaomi C.

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.20 MB

english, 2018

18

Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD

Wang, Wei, Tanokashira, Daisuke, Fukui, Yusuke, Maruyama, Megumi, Kuroiwa, Chiemi, Saito, Takashi, Saido, Takaomi C., Taguchi, Akiko

Journal:

Year:

2019

File:

PDF, 1.57 MB

2019

19

Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue

Tokiko Ogawa, Sumiko Kiryu-Seo, Masaaki Tanaka, Hiroyuki Konishi, Nobuhisa Iwata, Takaomi Saido, Yasuyoshi Watanabe, Hiroshi Kiyama

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 579 KB

english, 2005

20

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25

Ko Sato, Seiji Minegishi, Jiro Takano, Florian Plattner, Taro Saito, Akiko Asada, Hiroyuki Kawahara, Nobuhisa Iwata, Takaomi C. Saido, Shin-ichi Hisanaga

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 544 KB

english, 2011

21

Analysis and utilization of beta-amyloid degradation system

Takaomi C. SAIDO

Journal:

Psychogeriatrics

Year:

2004

Language:

english

File:

PDF, 582 KB

english, 2004

22

Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury

Kathleen M. Schoch, Heather N. Evans, Jennifer M. Brelsfoard, Sindhu K. Madathil, Jiro Takano, Takaomi C. Saido, Kathryn E. Saatman

Journal:

Experimental Neurology

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

23

Induction of increased calcium uptake in liposomes having membrane proteins of chicken erythrocytes by S-adenosylmethionine

Satoshi Toyoshima, Takaomi Saido, Fusao Makishima, Toshiaki Osawa

Journal:

Biochemical and Biophysical Research Communications

Year:

1983

Language:

english

File:

PDF, 393 KB

english, 1983

24

Stimulation of protein-tyrosine phosphorylation in gerbil hippocampus after global forebrain ischemia

Yokota, Masayuki, Saido, Takaomi C., Miyaji, Katsuya, Tani, Eiichi, Kawashima, Seiichi, Suzuki, Koichi

Journal:

Neuroscience Letters

Year:

1994

Language:

english

File:

PDF, 577 KB

english, 1994

25

Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum

Yoko Sekine-Aizawa, Emi Hama, Kaori Watanabe, Satoshi Tsubuki, Masami Kanai-Azuma, Yoshiakira Kanai, Hiroyuki Arai, Hiroyuki Aizawa, Nobuhisa Iwata, Takaomi C. Saido

Journal:

European Journal of Neuroscience

Year:

2001

Language:

english

File:

PDF, 1.41 MB

english, 2001

26

Discussions on role of neprilysin and degradating system

Takaomi C. SAIDO, Masatoshi TAKEDA, Katsuya URAKAMI, Mikio SHOJI, Nobuo ITO, Takeshi IWATSUBO, Akira TAMAOKA, Kazutomi KANEMARU

Journal:

Psychogeriatrics

Year:

2004

Language:

english

File:

PDF, 62 KB

english, 2004

27

Alzheimer's β-secretase cleaves a glycosyltransferase as a physiological substrate

Shinobu Kitazume, Takaomi C. Saido, Yasuhiro Hashimoto

Journal:

Glycoconjugate Journal

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003

28

Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices

Eric Bednarski, Peter Vanderklish, Christine Gall, Takaomi C. Saido, Ben A. Bahr, Gary Lynch

Journal:

Year:

1995

Language:

english

File:

PDF, 1.58 MB

english, 1995

29

Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells

Elisabetta Daré, Roshan Tofighi, Maria Vittoria Vettori, Takashi Momoi, Diana Poli, Takaomi C Saido, Antonio Mutti, Sandra Ceccatelli

Journal:

Year:

2002

Language:

english

File:

PDF, 646 KB

english, 2002

30

Activation of μ-calpain in developing cortical neurons following methylmercury treatment

Jian Zhang, Ken-ichiro Miyamoto, Sadayuki Hashioka, Hai Peng Hao, Koji Murao, Takaomi C. Saido, Hiroshi Nakanishi

Journal:

Developmental Brain Research

Year:

2003

Language:

english

File:

PDF, 693 KB

english, 2003

31

PS-Liposome and Ox-LDL Bind to Different Sites of the Immunodominant Domain (#155-183) of CD36: A Study with GS95, a New Anti-CD36 Monoclonal Antibody

Atsumi Yamaguchi, Naomasa Yamamoto, Noriko Akamatsu, Takaomi C Saido, Mizuho Kaneda, Masato Umeda, Kenjiro Tanoue

Journal:

Thrombosis Research

Year:

2000

Language:

english

File:

PDF, 201 KB

english, 2000

32

The Presenilin 2 Mutation (N141I) Linked to Familial Alzheimer Disease (Volga German Families) Increases the Secretion of Amyloid β Protein Ending at the 42nd (or 43rd) Residue

Taisuke Tomita, Kei Maruyama, Takaomi C. Saido, Hideaki Kume, Kohki Shinozaki, Shinya Tokuhiro, Anja Capell, Jochen Walter, Jürgen Grünberg, Christian Haass, Takeshi Iwatsubo and Kunihiko Obata

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.15 MB

english, 1997

33

ScaleS: an optical clearing palette for biological imaging

Hama, Hiroshi, Hioki, Hiroyuki, Namiki, Kana, Hoshida, Tetsushi, Kurokawa, Hiroshi, Ishidate, Fumiyoshi, Kaneko, Takeshi, Akagi, Takumi, Saito, Takashi, Saido, Takaomi, Miyawaki, Atsushi

Journal:

Nature Neuroscience

Year:

2015

Language:

english

File:

PDF, 6.41 MB

english, 2015

34

NEURON-SPECIFIC METHYLOME ANALYSIS REVEALS NEW PATHOMECHANISM IN ALZHEIMER’S DISEASE BRAINS

Iwata, Atsushi, Mano, Tatsuo, Ohtomo, Ryo, Nagata, Kenichi, Saido, Takaomi C., Yamashita, Satoshi, Ushijima, Toshikazu, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Tamaoka, Akira, Tsuji, Shoji

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 56 KB

english, 2016

35

The disease-modifying drug candidate, SAK3 improves cognitive impairment and inhibits amyloid beta deposition in App knock-in mice.

Izumi, Hisanao, Shinoda, Yasuharu, Saito, Takashi, Saido, Takaomi, Sato, Keita, Yabuki, Yasushi, Matsumoto, Yotaro, Kanemitsu, Yoshitomi, Tomioka, Yoshihisa, Abolhassani, Nona, Nakabeppu, Yusaku, Fuku

Journal:

Year:

2018

Language:

english

File:

PDF, 1.14 MB

english, 2018

36

Neuroinflammation in mouse models of Alzheimer's disease

Saito, Takashi, Saido, Takaomi C.

Journal:

Clinical and Experimental Neuroimmunology

Year:

2018

Language:

english

File:

PDF, 529 KB

english, 2018

37

DECREASE IN AMYLOID PLAQUE FORMATION BY DISEASE-MODIFYING DRUG SAK3 IN APP KNOCK-IN MICE

Fukunaga, Kohji, Izumi, Hisanao, Shinoda, Yasuharu, Yabuki, Yasushi, Saito, Takashi, Saido, Takaomi C.

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 96 KB

english, 2018

38

App mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation

Hamaguchi, Takuya, Tsutsui-Kimura, Iku, Mimura, Masaru, Saito, Takashi, Saido, Takaomi C., Tanaka, Kenji F.

Journal:

Neurochemistry International

Year:

2019

Language:

english

File:

PDF, 1.72 MB

english, 2019

39

Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimerâs Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice

Hongo, Nobuko, Takamura, Yusaku, Nishimaru, Hiroshi, Matsumoto, Jumpei, Tobe, Kazuyuki, Saito, Takashi, Saido, Takaomi C., Nishijo, Hisao

Journal:

Frontiers in Pharmacology

Year:

2020

File:

PDF, 1.69 MB

2020

40

Amyloid Î² induces interneuron-specific changes in the hippocampus of APPNL-F mice

Sos, Katalin E., Mayer, MÃ¡rton I., TakÃ¡cs, VirÃ¡g T., Major, Abel, BardÃ³czi, Zsuzsanna, Beres, Barnabas M., Szeles, TamÃ¡s, Saito, Takashi, Saido, Takaomi C., Mody, IstvÃ¡n, Freund, TamÃ¡s F., Nyir

Journal:

Year:

2020

File:

PDF, 3.85 MB

2020

41

Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques

Kumi Sato, Makoto Higuchi, Nobuhisa Iwata, Takaomi C Saido, Kazumi Sasamoto

Journal:

European Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 445 KB

english, 2004

42

Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2

Won-Seok Choi, Eun-Hee Lee, Chul-Woong Chung, Yong-Keun Jung, Byung K. Jin, Seung U. Kim, Tae H. Oh, Takaomi C. Saido, Young J. Oh

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 872 KB

english, 2001

43

Enhanced accumulation of tau in doubly transgenic mice expressing mutant βAPP and presenilin-1

Eriko Samura, Mikio Shoji, Takeshi Kawarabayashi, Atsushi Sasaki, Etsuro Matsubara, Tetsuro Murakami, Xu Wuhua, Shuta Tamura, Masaki Ikeda, Koich Ishiguro, Takaomi C. Saido, David Westaway, Peter St.

Journal:

Year:

2006

Language:

english

File:

PDF, 770 KB

english, 2006

44

Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid β and impairment of learning and memory

Akihiro Mouri, Li-Bo Zou, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Yukihiro Noda, Toshitaka Nabeshima

Journal:

Behavioural Brain Research

Year:

2006

Language:

english

File:

PDF, 218 KB

english, 2006

45

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yasumasa Yoshiyama, Makoto Higuchi, Bin Zhang, Shu-Ming Huang, Nobuhisa Iwata, Takaomi C. Saido, Jun Maeda, Tetsuya Suhara, John Q. Trojanowski, Virginia M.-Y. Lee

Journal:

Year:

2007

Language:

english

File:

PDF, 4.40 MB

english, 2007

46

Intraneuronal Aβ42 immunoreactivity is inversely correlated with Alzheimer's disease pathology in down syndrome brain: A temporal study

Chica Mori, Krystyna Wisniewski, Thomas Wisniewski, Takaomi C. Saido, Dennis J. Selkoe, Cynthia A. Lemere

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 197 KB

english, 2000

47

APP knock-in mouse: A novel and more relevant model mouse for Alzheimer's disease

Takashi Saito, Yukio Matsuba, Naomi Mihira, Nobuhisa Iwata, Jiro Takano, Per Nilsson, Takaomi Saido

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 138 KB

english, 2012

48

813 Quantitative analysis of amyloid B protein with amino-terminal pyroglutamate 3 in alzheimer's disease brains

Yasuo Harigaya, Takaomi C. Saido, Mikio Shoji, Steven G. Younkin

Journal:

Neuroscience Research

Year:

1997

Language:

english

File:

PDF, 103 KB

english, 1997

49

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, Erika, Leon, Julio, Mazzei, Guianfranco, Abolhassani, Nona, Haruyama, Naoki, Saito, Takashi, Saido, Takaomi, Hokama, Masaaki, Iwaki, Toru, Ohara, Tomoyuki, Ninomiya, Toshiharu, Kiyohara, Yut

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 5.43 MB

english, 2017

50

IMMUNOHISTOLOGICAL ANALYSIS OF AMYLOID-β OLIGOMER DEPOSITS IN APP KNOCK-IN MICE

Furukawa, Fumiko, Sanjo, Nobuo, Nishida, Yoichiro, Matsubara, Etsuro, Akiba, Hiroki, Kohei, Tsumoto, Saito, Takashi, Saido, Takaomi C., Yokota, Takanori

Journal:

Alzheimer's & Dementia

Year:

2017

Language:

english

File:

PDF, 341 KB

english, 2017

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